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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Eckhardt, Sarah | D | 760 | 2235 | 34.00% | ||
| Gutierrez, Roland | D | 732 | 2294 | 31.91% | ||
| Johnson, Nathan | D | 704 | 2405 | 29.27% | ||
| Miles, Borris | D | 690 | 2402 | 28.73% | ||
| Menéndez, José | D | 686 | 2408 | 28.49% | ||
| Alvarado, Carol | D | 683 | 2408 | 28.36% | ||
| West, Royce | D | 658 | 2320 | 28.36% | ||
| Whitmire, John | D | 680 | 2408 | 28.24% | ||
| Zaffirini, Judith | D | 664 | 2408 | 27.57% | ||
| LaMantia, Morgan | D | 652 | 2397 | 27.20% | ||
| Blanco, César | D | 638 | 2408 | 26.50% | ||
| Hinojosa, Juan | D | 539 | 2402 | 22.44% | ||
| Nichols, Robert | R | 369 | 2405 | 15.34% | ||
| Perry, Charles | R | 359 | 2408 | 14.91% | ||
| Schwertner, Charles | R | 336 | 2408 | 13.95% | ||
| Springer, Drew | R | 319 | 2408 | 13.25% | ||
| Flores, Pete | R | 316 | 2408 | 13.12% | ||
| Huffman, Joan | R | 315 | 2408 | 13.08% | ||
| Creighton, Brandon | R | 312 | 2408 | 12.96% | ||
| Birdwell, Brian | R | 296 | 2316 | 12.78% | ||
| Campbell, Donna | R | 303 | 2408 | 12.58% | ||
| Sparks, Kevin | R | 285 | 2316 | 12.31% | ||
| King, Phil | R | 278 | 2270 | 12.25% | ||
| Paxton, Angela | R | 286 | 2408 | 11.88% | ||
| Parker, Tan | R | 279 | 2408 | 11.59% | ||
| Hancock, Kelly | R | 274 | 2405 | 11.39% | ||
| Bettencourt, Paul | R | 266 | 2354 | 11.30% | ||
| Middleton, Mayes | R | 261 | 2408 | 10.84% | ||
| Kolkhorst, Lois | R | 242 | 2354 | 10.28% | ||
| Hughes, Bryan | R | 204 | 2408 | 8.47% | ||
| Hall, Bob | R | 0 | 2408 | 0.00% |
