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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Eckhardt, Sarah | D | 505 | 2232 | 22.63% | ||
| Gutierrez, Roland | D | 466 | 2291 | 20.34% | ||
| Johnson, Nathan | D | 412 | 2402 | 17.15% | ||
| Menéndez, José | D | 412 | 2405 | 17.13% | ||
| Miles, Borris | D | 406 | 2402 | 16.90% | ||
| Alvarado, Carol | D | 405 | 2405 | 16.84% | ||
| Hughes, Bryan | R | 403 | 2405 | 16.76% | ||
| Whitmire, John | D | 402 | 2405 | 16.72% | ||
| West, Royce | D | 386 | 2317 | 16.66% | ||
| Middleton, Mayes | R | 388 | 2405 | 16.13% | ||
| Zaffirini, Judith | D | 378 | 2405 | 15.72% | ||
| Hall, Bob | R | 369 | 2405 | 15.34% | ||
| LaMantia, Morgan | D | 366 | 2394 | 15.29% | ||
| Blanco, César | D | 360 | 2405 | 14.97% | ||
| Hinojosa, Juan | D | 239 | 2399 | 9.96% | ||
| Springer, Drew | R | 206 | 2405 | 8.57% | ||
| Creighton, Brandon | R | 165 | 2405 | 6.86% | ||
| Schwertner, Charles | R | 147 | 2405 | 6.11% | ||
| Hancock, Kelly | R | 146 | 2402 | 6.08% | ||
| Kolkhorst, Lois | R | 142 | 2351 | 6.04% | ||
| Bettencourt, Paul | R | 120 | 2351 | 5.10% | ||
| Sparks, Kevin | R | 114 | 2313 | 4.93% | ||
| Parker, Tan | R | 118 | 2405 | 4.91% | ||
| King, Phil | R | 111 | 2267 | 4.90% | ||
| Paxton, Angela | R | 109 | 2405 | 4.53% | ||
| Perry, Charles | R | 108 | 2405 | 4.49% | ||
| Campbell, Donna | R | 96 | 2405 | 3.99% | ||
| Birdwell, Brian | R | 87 | 2313 | 3.76% | ||
| Flores, Pete | R | 73 | 2405 | 3.04% | ||
| Huffman, Joan | R | 72 | 2405 | 2.99% | ||
| Nichols, Robert | R | 0 | 2405 | 0.00% |
