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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Eckhardt, Sarah | D | 604 | 2235 | 27.02% | ||
| Gutierrez, Roland | D | 569 | 2294 | 24.80% | ||
| Johnson, Nathan | D | 522 | 2405 | 21.70% | ||
| Menéndez, José | D | 520 | 2408 | 21.59% | ||
| Miles, Borris | D | 515 | 2402 | 21.44% | ||
| Alvarado, Carol | D | 513 | 2408 | 21.30% | ||
| Whitmire, John | D | 504 | 2408 | 20.93% | ||
| West, Royce | D | 485 | 2320 | 20.91% | ||
| Zaffirini, Judith | D | 482 | 2408 | 20.02% | ||
| LaMantia, Morgan | D | 466 | 2397 | 19.44% | ||
| Blanco, César | D | 466 | 2408 | 19.35% | ||
| Middleton, Mayes | R | 347 | 2408 | 14.41% | ||
| Hinojosa, Juan | D | 343 | 2402 | 14.28% | ||
| Hughes, Bryan | R | 338 | 2408 | 14.04% | ||
| Hall, Bob | R | 312 | 2408 | 12.96% | ||
| Springer, Drew | R | 181 | 2408 | 7.52% | ||
| Schwertner, Charles | R | 180 | 2408 | 7.48% | ||
| Nichols, Robert | R | 165 | 2405 | 6.86% | ||
| Perry, Charles | R | 165 | 2408 | 6.85% | ||
| Kolkhorst, Lois | R | 153 | 2354 | 6.50% | ||
| Hancock, Kelly | R | 155 | 2405 | 6.44% | ||
| Sparks, Kevin | R | 137 | 2316 | 5.92% | ||
| Campbell, Donna | R | 137 | 2408 | 5.69% | ||
| Parker, Tan | R | 137 | 2408 | 5.69% | ||
| King, Phil | R | 129 | 2270 | 5.68% | ||
| Birdwell, Brian | R | 124 | 2316 | 5.35% | ||
| Huffman, Joan | R | 125 | 2408 | 5.19% | ||
| Paxton, Angela | R | 120 | 2408 | 4.98% | ||
| Bettencourt, Paul | R | 114 | 2354 | 4.84% | ||
| Flores, Pete | R | 114 | 2408 | 4.73% | ||
| Creighton, Brandon | R | 0 | 2408 | 0.00% |
