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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Eckhardt, Sarah | D | 576 | 2235 | 25.77% | ||
| Gutierrez, Roland | D | 550 | 2294 | 23.98% | ||
| Menéndez, José | D | 500 | 2408 | 20.76% | ||
| Miles, Borris | D | 497 | 2402 | 20.69% | ||
| Johnson, Nathan | D | 496 | 2405 | 20.62% | ||
| Alvarado, Carol | D | 493 | 2408 | 20.47% | ||
| Whitmire, John | D | 484 | 2408 | 20.10% | ||
| West, Royce | D | 465 | 2320 | 20.04% | ||
| Zaffirini, Judith | D | 462 | 2408 | 19.19% | ||
| LaMantia, Morgan | D | 446 | 2397 | 18.61% | ||
| Blanco, César | D | 448 | 2408 | 18.60% | ||
| Hughes, Bryan | R | 366 | 2408 | 15.20% | ||
| Middleton, Mayes | R | 361 | 2408 | 14.99% | ||
| Hall, Bob | R | 336 | 2408 | 13.95% | ||
| Hinojosa, Juan | D | 325 | 2402 | 13.53% | ||
| Springer, Drew | R | 219 | 2408 | 9.09% | ||
| Creighton, Brandon | R | 180 | 2408 | 7.48% | ||
| Hancock, Kelly | R | 157 | 2405 | 6.53% | ||
| Nichols, Robert | R | 147 | 2405 | 6.11% | ||
| Bettencourt, Paul | R | 143 | 2354 | 6.07% | ||
| Kolkhorst, Lois | R | 143 | 2354 | 6.07% | ||
| Perry, Charles | R | 143 | 2408 | 5.94% | ||
| Sparks, Kevin | R | 134 | 2316 | 5.79% | ||
| Paxton, Angela | R | 118 | 2408 | 4.90% | ||
| Campbell, Donna | R | 117 | 2408 | 4.86% | ||
| King, Phil | R | 107 | 2270 | 4.71% | ||
| Birdwell, Brian | R | 107 | 2316 | 4.62% | ||
| Parker, Tan | R | 109 | 2408 | 4.53% | ||
| Huffman, Joan | R | 107 | 2408 | 4.44% | ||
| Flores, Pete | R | 102 | 2408 | 4.24% | ||
| Schwertner, Charles | R | 0 | 2408 | 0.00% |
