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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Hughes, Bryan | R | 765 | 2408 | 31.77% | ||
| Middleton, Mayes | R | 750 | 2408 | 31.15% | ||
| Hall, Bob | R | 683 | 2408 | 28.36% | ||
| Springer, Drew | R | 558 | 2408 | 23.17% | ||
| Creighton, Brandon | R | 513 | 2408 | 21.30% | ||
| Kolkhorst, Lois | R | 494 | 2354 | 20.99% | ||
| Schwertner, Charles | R | 493 | 2408 | 20.47% | ||
| Hancock, Kelly | R | 484 | 2405 | 20.12% | ||
| King, Phil | R | 444 | 2270 | 19.56% | ||
| Bettencourt, Paul | R | 450 | 2354 | 19.12% | ||
| Perry, Charles | R | 454 | 2408 | 18.85% | ||
| Parker, Tan | R | 452 | 2408 | 18.77% | ||
| Sparks, Kevin | R | 432 | 2316 | 18.65% | ||
| Paxton, Angela | R | 443 | 2408 | 18.40% | ||
| Campbell, Donna | R | 436 | 2408 | 18.11% | ||
| Huffman, Joan | R | 422 | 2408 | 17.52% | ||
| Birdwell, Brian | R | 393 | 2316 | 16.97% | ||
| Flores, Pete | R | 407 | 2408 | 16.90% | ||
| Nichols, Robert | R | 405 | 2405 | 16.84% | ||
| Hinojosa, Juan | D | 192 | 2402 | 7.99% | ||
| West, Royce | D | 176 | 2320 | 7.59% | ||
| Eckhardt, Sarah | D | 146 | 2235 | 6.53% | ||
| Johnson, Nathan | D | 124 | 2405 | 5.16% | ||
| Gutierrez, Roland | D | 108 | 2294 | 4.71% | ||
| Zaffirini, Judith | D | 111 | 2408 | 4.61% | ||
| Blanco, César | D | 89 | 2408 | 3.70% | ||
| LaMantia, Morgan | D | 88 | 2397 | 3.67% | ||
| Menéndez, José | D | 79 | 2408 | 3.28% | ||
| Miles, Borris | D | 72 | 2402 | 3.00% | ||
| Whitmire, John | D | 35 | 2408 | 1.45% | ||
| Alvarado, Carol | D | 0 | 2408 | 0.00% |
