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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Eckhardt, Sarah | D | 540 | 2181 | 24.76% | ||
| Gutierrez, Roland | D | 516 | 2240 | 23.04% | ||
| Johnson, Nathan | D | 462 | 2351 | 19.65% | ||
| Menéndez, José | D | 457 | 2354 | 19.41% | ||
| Alvarado, Carol | D | 450 | 2354 | 19.12% | ||
| Miles, Borris | D | 448 | 2348 | 19.08% | ||
| West, Royce | D | 425 | 2266 | 18.76% | ||
| Whitmire, John | D | 441 | 2354 | 18.73% | ||
| Zaffirini, Judith | D | 419 | 2354 | 17.80% | ||
| LaMantia, Morgan | D | 406 | 2343 | 17.33% | ||
| Blanco, César | D | 401 | 2354 | 17.03% | ||
| Hughes, Bryan | R | 304 | 2354 | 12.91% | ||
| Middleton, Mayes | R | 297 | 2354 | 12.62% | ||
| Hinojosa, Juan | D | 279 | 2348 | 11.88% | ||
| Hall, Bob | R | 266 | 2354 | 11.30% | ||
| Springer, Drew | R | 147 | 2354 | 6.24% | ||
| Schwertner, Charles | R | 143 | 2354 | 6.07% | ||
| Nichols, Robert | R | 120 | 2351 | 5.10% | ||
| Perry, Charles | R | 118 | 2354 | 5.01% | ||
| Creighton, Brandon | R | 114 | 2354 | 4.84% | ||
| Hancock, Kelly | R | 108 | 2351 | 4.59% | ||
| King, Phil | R | 89 | 2216 | 4.02% | ||
| Parker, Tan | R | 90 | 2354 | 3.82% | ||
| Kolkhorst, Lois | R | 86 | 2300 | 3.74% | ||
| Campbell, Donna | R | 83 | 2354 | 3.53% | ||
| Sparks, Kevin | R | 77 | 2262 | 3.40% | ||
| Birdwell, Brian | R | 76 | 2262 | 3.36% | ||
| Paxton, Angela | R | 77 | 2354 | 3.27% | ||
| Flores, Pete | R | 65 | 2354 | 2.76% | ||
| Huffman, Joan | R | 62 | 2354 | 2.63% | ||
| Bettencourt, Paul | R | 0 | 2354 | 0.00% |
