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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Eckhardt, Sarah | D | 537 | 2235 | 24.03% | ||
| Gutierrez, Roland | D | 508 | 2294 | 22.14% | ||
| Johnson, Nathan | D | 452 | 2405 | 18.79% | ||
| Miles, Borris | D | 450 | 2402 | 18.73% | ||
| Menéndez, José | D | 450 | 2408 | 18.69% | ||
| Alvarado, Carol | D | 443 | 2408 | 18.40% | ||
| Whitmire, John | D | 438 | 2408 | 18.19% | ||
| West, Royce | D | 409 | 2320 | 17.63% | ||
| Zaffirini, Judith | D | 418 | 2408 | 17.36% | ||
| Blanco, César | D | 398 | 2408 | 16.53% | ||
| LaMantia, Morgan | D | 390 | 2397 | 16.27% | ||
| Hughes, Bryan | R | 328 | 2408 | 13.62% | ||
| Middleton, Mayes | R | 319 | 2408 | 13.25% | ||
| Hall, Bob | R | 286 | 2408 | 11.88% | ||
| Hinojosa, Juan | D | 281 | 2402 | 11.70% | ||
| Springer, Drew | R | 151 | 2408 | 6.27% | ||
| Creighton, Brandon | R | 120 | 2408 | 4.98% | ||
| Schwertner, Charles | R | 118 | 2408 | 4.90% | ||
| Kolkhorst, Lois | R | 111 | 2354 | 4.72% | ||
| Nichols, Robert | R | 109 | 2405 | 4.53% | ||
| Perry, Charles | R | 99 | 2408 | 4.11% | ||
| Hancock, Kelly | R | 91 | 2405 | 3.78% | ||
| Bettencourt, Paul | R | 77 | 2354 | 3.27% | ||
| Campbell, Donna | R | 77 | 2408 | 3.20% | ||
| Sparks, Kevin | R | 71 | 2316 | 3.07% | ||
| Parker, Tan | R | 71 | 2408 | 2.95% | ||
| King, Phil | R | 64 | 2270 | 2.82% | ||
| Huffman, Joan | R | 61 | 2408 | 2.53% | ||
| Flores, Pete | R | 52 | 2408 | 2.16% | ||
| Birdwell, Brian | R | 40 | 2316 | 1.73% | ||
| Paxton, Angela | R | 0 | 2408 | 0.00% |
