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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Eckhardt, Sarah | D | 808 | 2235 | 36.15% | ||
| Gutierrez, Roland | D | 800 | 2294 | 34.87% | ||
| Johnson, Nathan | D | 761 | 2405 | 31.64% | ||
| Menéndez, José | D | 759 | 2408 | 31.52% | ||
| Miles, Borris | D | 750 | 2402 | 31.22% | ||
| Alvarado, Carol | D | 750 | 2408 | 31.15% | ||
| West, Royce | D | 715 | 2320 | 30.82% | ||
| Whitmire, John | D | 741 | 2408 | 30.77% | ||
| Zaffirini, Judith | D | 719 | 2408 | 29.86% | ||
| LaMantia, Morgan | D | 703 | 2397 | 29.33% | ||
| Blanco, César | D | 699 | 2408 | 29.03% | ||
| Hinojosa, Juan | D | 578 | 2402 | 24.06% | ||
| Nichols, Robert | R | 388 | 2405 | 16.13% | ||
| Perry, Charles | R | 370 | 2408 | 15.37% | ||
| Schwertner, Charles | R | 361 | 2408 | 14.99% | ||
| Flores, Pete | R | 349 | 2408 | 14.49% | ||
| Campbell, Donna | R | 348 | 2408 | 14.45% | ||
| Creighton, Brandon | R | 347 | 2408 | 14.41% | ||
| Birdwell, Brian | R | 332 | 2316 | 14.34% | ||
| Huffman, Joan | R | 340 | 2408 | 14.12% | ||
| Sparks, Kevin | R | 313 | 2316 | 13.51% | ||
| Paxton, Angela | R | 319 | 2408 | 13.25% | ||
| Hancock, Kelly | R | 313 | 2405 | 13.01% | ||
| Parker, Tan | R | 312 | 2408 | 12.96% | ||
| Bettencourt, Paul | R | 297 | 2354 | 12.62% | ||
| Springer, Drew | R | 296 | 2408 | 12.29% | ||
| King, Phil | R | 266 | 2270 | 11.72% | ||
| Hall, Bob | R | 261 | 2408 | 10.84% | ||
| Kolkhorst, Lois | R | 243 | 2354 | 10.32% | ||
| Hughes, Bryan | R | 175 | 2408 | 7.27% | ||
| Middleton, Mayes | R | 0 | 2408 | 0.00% |
