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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Eckhardt, Sarah | D | 549 | 2235 | 24.56% | ||
| Gutierrez, Roland | D | 529 | 2294 | 23.06% | ||
| Johnson, Nathan | D | 461 | 2405 | 19.17% | ||
| Menéndez, José | D | 459 | 2408 | 19.06% | ||
| Miles, Borris | D | 453 | 2402 | 18.86% | ||
| Alvarado, Carol | D | 452 | 2408 | 18.77% | ||
| Whitmire, John | D | 449 | 2408 | 18.65% | ||
| West, Royce | D | 422 | 2320 | 18.19% | ||
| Zaffirini, Judith | D | 427 | 2408 | 17.73% | ||
| LaMantia, Morgan | D | 405 | 2397 | 16.90% | ||
| Blanco, César | D | 401 | 2408 | 16.65% | ||
| Hughes, Bryan | R | 329 | 2408 | 13.66% | ||
| Middleton, Mayes | R | 312 | 2408 | 12.96% | ||
| Hinojosa, Juan | D | 284 | 2402 | 11.82% | ||
| Hall, Bob | R | 279 | 2408 | 11.59% | ||
| Springer, Drew | R | 176 | 2408 | 7.31% | ||
| Creighton, Brandon | R | 137 | 2408 | 5.69% | ||
| Nichols, Robert | R | 118 | 2405 | 4.91% | ||
| Schwertner, Charles | R | 109 | 2408 | 4.53% | ||
| Perry, Charles | R | 108 | 2408 | 4.49% | ||
| Kolkhorst, Lois | R | 91 | 2354 | 3.87% | ||
| Hancock, Kelly | R | 92 | 2405 | 3.83% | ||
| Bettencourt, Paul | R | 90 | 2354 | 3.82% | ||
| Sparks, Kevin | R | 73 | 2316 | 3.15% | ||
| Paxton, Angela | R | 71 | 2408 | 2.95% | ||
| Huffman, Joan | R | 68 | 2408 | 2.82% | ||
| Flores, Pete | R | 67 | 2408 | 2.78% | ||
| Campbell, Donna | R | 66 | 2408 | 2.74% | ||
| King, Phil | R | 59 | 2270 | 2.60% | ||
| Birdwell, Brian | R | 60 | 2316 | 2.59% | ||
| Parker, Tan | R | 0 | 2408 | 0.00% |
