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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Hughes, Bryan | R | 768 | 2405 | 31.93% | ||
| Middleton, Mayes | R | 761 | 2405 | 31.64% | ||
| Hall, Bob | R | 704 | 2405 | 29.27% | ||
| Springer, Drew | R | 567 | 2405 | 23.58% | ||
| Creighton, Brandon | R | 522 | 2405 | 21.70% | ||
| Kolkhorst, Lois | R | 503 | 2351 | 21.40% | ||
| Schwertner, Charles | R | 496 | 2405 | 20.62% | ||
| Hancock, Kelly | R | 495 | 2402 | 20.61% | ||
| King, Phil | R | 451 | 2267 | 19.89% | ||
| Bettencourt, Paul | R | 462 | 2351 | 19.65% | ||
| Parker, Tan | R | 461 | 2405 | 19.17% | ||
| Sparks, Kevin | R | 440 | 2313 | 19.02% | ||
| Perry, Charles | R | 453 | 2405 | 18.84% | ||
| Paxton, Angela | R | 452 | 2405 | 18.79% | ||
| Campbell, Donna | R | 445 | 2405 | 18.50% | ||
| Huffman, Joan | R | 427 | 2405 | 17.75% | ||
| Flores, Pete | R | 416 | 2405 | 17.30% | ||
| Nichols, Robert | R | 412 | 2402 | 17.15% | ||
| Birdwell, Brian | R | 395 | 2313 | 17.08% | ||
| Hinojosa, Juan | D | 203 | 2402 | 8.45% | ||
| West, Royce | D | 190 | 2318 | 8.20% | ||
| Eckhardt, Sarah | D | 181 | 2232 | 8.11% | ||
| Blanco, César | D | 163 | 2405 | 6.78% | ||
| Gutierrez, Roland | D | 138 | 2291 | 6.02% | ||
| Menéndez, José | D | 144 | 2405 | 5.99% | ||
| Miles, Borris | D | 142 | 2399 | 5.92% | ||
| Zaffirini, Judith | D | 129 | 2405 | 5.36% | ||
| Whitmire, John | D | 127 | 2405 | 5.28% | ||
| Alvarado, Carol | D | 124 | 2405 | 5.16% | ||
| LaMantia, Morgan | D | 119 | 2394 | 4.97% | ||
| Johnson, Nathan | D | 0 | 2405 | 0.00% |
