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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Eckhardt, Sarah | D | 581 | 2184 | 26.60% | ||
| Gutierrez, Roland | D | 546 | 2240 | 24.38% | ||
| Johnson, Nathan | D | 503 | 2351 | 21.40% | ||
| Menéndez, José | D | 501 | 2354 | 21.28% | ||
| Alvarado, Carol | D | 494 | 2354 | 20.99% | ||
| Miles, Borris | D | 492 | 2348 | 20.95% | ||
| Whitmire, John | D | 485 | 2354 | 20.60% | ||
| West, Royce | D | 463 | 2266 | 20.43% | ||
| Zaffirini, Judith | D | 463 | 2354 | 19.67% | ||
| LaMantia, Morgan | D | 447 | 2343 | 19.08% | ||
| Blanco, César | D | 443 | 2354 | 18.82% | ||
| Hinojosa, Juan | D | 320 | 2348 | 13.63% | ||
| Hughes, Bryan | R | 268 | 2354 | 11.38% | ||
| Middleton, Mayes | R | 243 | 2354 | 10.32% | ||
| Hall, Bob | R | 242 | 2354 | 10.28% | ||
| Springer, Drew | R | 170 | 2354 | 7.22% | ||
| Creighton, Brandon | R | 153 | 2354 | 6.50% | ||
| Schwertner, Charles | R | 143 | 2354 | 6.07% | ||
| Nichols, Robert | R | 142 | 2351 | 6.04% | ||
| Paxton, Angela | R | 111 | 2354 | 4.72% | ||
| King, Phil | R | 104 | 2216 | 4.69% | ||
| Hancock, Kelly | R | 110 | 2351 | 4.68% | ||
| Perry, Charles | R | 108 | 2354 | 4.59% | ||
| Birdwell, Brian | R | 100 | 2262 | 4.42% | ||
| Sparks, Kevin | R | 97 | 2262 | 4.29% | ||
| Campbell, Donna | R | 98 | 2354 | 4.16% | ||
| Flores, Pete | R | 97 | 2354 | 4.12% | ||
| Parker, Tan | R | 91 | 2354 | 3.87% | ||
| Bettencourt, Paul | R | 86 | 2300 | 3.74% | ||
| Huffman, Joan | R | 88 | 2354 | 3.74% | ||
| Kolkhorst, Lois | R | 0 | 2354 | 0.00% |
