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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Hughes, Bryan | R | 819 | 2294 | 35.70% | ||
| Middleton, Mayes | R | 800 | 2294 | 34.87% | ||
| Hall, Bob | R | 732 | 2294 | 31.91% | ||
| Springer, Drew | R | 620 | 2294 | 27.03% | ||
| Creighton, Brandon | R | 569 | 2294 | 24.80% | ||
| Kolkhorst, Lois | R | 546 | 2240 | 24.38% | ||
| Schwertner, Charles | R | 550 | 2294 | 23.98% | ||
| Hancock, Kelly | R | 548 | 2291 | 23.92% | ||
| King, Phil | R | 507 | 2156 | 23.52% | ||
| Parker, Tan | R | 529 | 2294 | 23.06% | ||
| Bettencourt, Paul | R | 516 | 2240 | 23.04% | ||
| Sparks, Kevin | R | 499 | 2202 | 22.66% | ||
| Perry, Charles | R | 513 | 2294 | 22.36% | ||
| Campbell, Donna | R | 512 | 2294 | 22.32% | ||
| Paxton, Angela | R | 508 | 2294 | 22.14% | ||
| Huffman, Joan | R | 485 | 2294 | 21.14% | ||
| Flores, Pete | R | 476 | 2294 | 20.75% | ||
| Birdwell, Brian | R | 449 | 2202 | 20.39% | ||
| Nichols, Robert | R | 466 | 2291 | 20.34% | ||
| Hinojosa, Juan | D | 263 | 2288 | 11.49% | ||
| West, Royce | D | 170 | 2206 | 7.71% | ||
| Eckhardt, Sarah | D | 160 | 2121 | 7.54% | ||
| Blanco, César | D | 167 | 2294 | 7.28% | ||
| LaMantia, Morgan | D | 148 | 2286 | 6.47% | ||
| Johnson, Nathan | D | 138 | 2291 | 6.02% | ||
| Zaffirini, Judith | D | 138 | 2294 | 6.02% | ||
| Menéndez, José | D | 116 | 2294 | 5.06% | ||
| Miles, Borris | D | 110 | 2291 | 4.80% | ||
| Alvarado, Carol | D | 108 | 2294 | 4.71% | ||
| Whitmire, John | D | 108 | 2294 | 4.71% | ||
| Gutierrez, Roland | D | 0 | 2294 | 0.00% |
