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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Hughes, Bryan | R | 603 | 2402 | 25.10% | ||
| Middleton, Mayes | R | 578 | 2402 | 24.06% | ||
| Hall, Bob | R | 539 | 2402 | 22.44% | ||
| Springer, Drew | R | 384 | 2402 | 15.99% | ||
| Creighton, Brandon | R | 343 | 2402 | 14.28% | ||
| Kolkhorst, Lois | R | 320 | 2348 | 13.63% | ||
| Schwertner, Charles | R | 325 | 2402 | 13.53% | ||
| Hancock, Kelly | R | 324 | 2399 | 13.51% | ||
| Eckhardt, Sarah | D | 287 | 2229 | 12.88% | ||
| Perry, Charles | R | 296 | 2402 | 12.32% | ||
| King, Phil | R | 278 | 2264 | 12.28% | ||
| Bettencourt, Paul | R | 279 | 2348 | 11.88% | ||
| Parker, Tan | R | 284 | 2402 | 11.82% | ||
| Paxton, Angela | R | 281 | 2402 | 11.70% | ||
| Sparks, Kevin | R | 267 | 2310 | 11.56% | ||
| Gutierrez, Roland | D | 263 | 2288 | 11.49% | ||
| Campbell, Donna | R | 262 | 2402 | 10.91% | ||
| Huffman, Joan | R | 248 | 2402 | 10.32% | ||
| Nichols, Robert | R | 239 | 2399 | 9.96% | ||
| Flores, Pete | R | 239 | 2402 | 9.95% | ||
| Birdwell, Brian | R | 228 | 2310 | 9.87% | ||
| West, Royce | D | 196 | 2315 | 8.47% | ||
| Johnson, Nathan | D | 203 | 2402 | 8.45% | ||
| Menéndez, José | D | 194 | 2402 | 8.08% | ||
| Alvarado, Carol | D | 192 | 2402 | 7.99% | ||
| Whitmire, John | D | 189 | 2402 | 7.87% | ||
| Miles, Borris | D | 187 | 2396 | 7.80% | ||
| Blanco, César | D | 159 | 2402 | 6.62% | ||
| Zaffirini, Judith | D | 158 | 2402 | 6.58% | ||
| LaMantia, Morgan | D | 146 | 2391 | 6.11% | ||
| Hinojosa, Juan | D | 0 | 2402 | 0.00% |
