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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Hughes, Bryan | R | 740 | 2408 | 30.73% | ||
| Middleton, Mayes | R | 719 | 2408 | 29.86% | ||
| Hall, Bob | R | 664 | 2408 | 27.57% | ||
| Springer, Drew | R | 527 | 2408 | 21.89% | ||
| Creighton, Brandon | R | 482 | 2408 | 20.02% | ||
| Kolkhorst, Lois | R | 463 | 2354 | 19.67% | ||
| Schwertner, Charles | R | 462 | 2408 | 19.19% | ||
| Hancock, Kelly | R | 461 | 2405 | 19.17% | ||
| King, Phil | R | 418 | 2270 | 18.41% | ||
| Perry, Charles | R | 429 | 2408 | 17.82% | ||
| Bettencourt, Paul | R | 419 | 2354 | 17.80% | ||
| Parker, Tan | R | 427 | 2408 | 17.73% | ||
| Sparks, Kevin | R | 404 | 2316 | 17.44% | ||
| Paxton, Angela | R | 418 | 2408 | 17.36% | ||
| Campbell, Donna | R | 405 | 2408 | 16.82% | ||
| Huffman, Joan | R | 391 | 2408 | 16.24% | ||
| Birdwell, Brian | R | 365 | 2316 | 15.76% | ||
| Nichols, Robert | R | 378 | 2405 | 15.72% | ||
| Flores, Pete | R | 372 | 2408 | 15.45% | ||
| Eckhardt, Sarah | D | 184 | 2235 | 8.23% | ||
| West, Royce | D | 170 | 2320 | 7.33% | ||
| Hinojosa, Juan | D | 158 | 2402 | 6.58% | ||
| Gutierrez, Roland | D | 138 | 2294 | 6.02% | ||
| Johnson, Nathan | D | 129 | 2405 | 5.36% | ||
| Miles, Borris | D | 126 | 2402 | 5.25% | ||
| Blanco, César | D | 118 | 2408 | 4.90% | ||
| Menéndez, José | D | 116 | 2408 | 4.82% | ||
| LaMantia, Morgan | D | 113 | 2397 | 4.71% | ||
| Alvarado, Carol | D | 111 | 2408 | 4.61% | ||
| Whitmire, John | D | 98 | 2408 | 4.07% | ||
| Zaffirini, Judith | D | 0 | 2408 | 0.00% |
