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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Eckhardt, Sarah | D | 480 | 2143 | 22.40% | ||
| Gutierrez, Roland | D | 449 | 2202 | 20.39% | ||
| Menéndez, José | D | 400 | 2316 | 17.27% | ||
| Johnson, Nathan | D | 395 | 2313 | 17.08% | ||
| Alvarado, Carol | D | 393 | 2316 | 16.97% | ||
| Miles, Borris | D | 391 | 2310 | 16.93% | ||
| Whitmire, John | D | 382 | 2316 | 16.49% | ||
| West, Royce | D | 359 | 2228 | 16.11% | ||
| Zaffirini, Judith | D | 365 | 2316 | 15.76% | ||
| Blanco, César | D | 345 | 2316 | 14.90% | ||
| Hughes, Bryan | R | 345 | 2316 | 14.90% | ||
| LaMantia, Morgan | D | 340 | 2305 | 14.75% | ||
| Middleton, Mayes | R | 332 | 2316 | 14.34% | ||
| Hall, Bob | R | 296 | 2316 | 12.78% | ||
| Hinojosa, Juan | D | 228 | 2310 | 9.87% | ||
| Springer, Drew | R | 148 | 2316 | 6.39% | ||
| Creighton, Brandon | R | 124 | 2316 | 5.35% | ||
| Schwertner, Charles | R | 107 | 2316 | 4.62% | ||
| Kolkhorst, Lois | R | 100 | 2262 | 4.42% | ||
| Nichols, Robert | R | 87 | 2313 | 3.76% | ||
| Hancock, Kelly | R | 83 | 2313 | 3.59% | ||
| Bettencourt, Paul | R | 76 | 2262 | 3.36% | ||
| King, Phil | R | 72 | 2178 | 3.31% | ||
| Perry, Charles | R | 74 | 2316 | 3.20% | ||
| Campbell, Donna | R | 65 | 2316 | 2.81% | ||
| Sparks, Kevin | R | 65 | 2316 | 2.81% | ||
| Parker, Tan | R | 60 | 2316 | 2.59% | ||
| Huffman, Joan | R | 45 | 2316 | 1.94% | ||
| Paxton, Angela | R | 40 | 2316 | 1.73% | ||
| Flores, Pete | R | 36 | 2316 | 1.55% | ||
| Birdwell, Brian | R | 0 | 2316 | 0.00% |
