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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Eckhardt, Sarah | D | 528 | 2235 | 23.62% | ||
| Gutierrez, Roland | D | 512 | 2294 | 22.32% | ||
| Johnson, Nathan | D | 445 | 2405 | 18.50% | ||
| Menéndez, José | D | 439 | 2408 | 18.23% | ||
| Alvarado, Carol | D | 436 | 2408 | 18.11% | ||
| Miles, Borris | D | 434 | 2402 | 18.07% | ||
| Whitmire, John | D | 427 | 2408 | 17.73% | ||
| West, Royce | D | 411 | 2320 | 17.72% | ||
| Zaffirini, Judith | D | 405 | 2408 | 16.82% | ||
| LaMantia, Morgan | D | 395 | 2397 | 16.48% | ||
| Blanco, César | D | 385 | 2408 | 15.99% | ||
| Hughes, Bryan | R | 351 | 2408 | 14.58% | ||
| Middleton, Mayes | R | 348 | 2408 | 14.45% | ||
| Hall, Bob | R | 303 | 2408 | 12.58% | ||
| Hinojosa, Juan | D | 262 | 2402 | 10.91% | ||
| Springer, Drew | R | 170 | 2408 | 7.06% | ||
| Creighton, Brandon | R | 137 | 2408 | 5.69% | ||
| Schwertner, Charles | R | 117 | 2408 | 4.86% | ||
| Perry, Charles | R | 104 | 2408 | 4.32% | ||
| Kolkhorst, Lois | R | 98 | 2354 | 4.16% | ||
| Hancock, Kelly | R | 100 | 2405 | 4.16% | ||
| Nichols, Robert | R | 96 | 2405 | 3.99% | ||
| Bettencourt, Paul | R | 83 | 2354 | 3.53% | ||
| Paxton, Angela | R | 77 | 2408 | 3.20% | ||
| King, Phil | R | 70 | 2270 | 3.08% | ||
| Birdwell, Brian | R | 65 | 2316 | 2.81% | ||
| Parker, Tan | R | 66 | 2408 | 2.74% | ||
| Sparks, Kevin | R | 62 | 2316 | 2.68% | ||
| Huffman, Joan | R | 46 | 2408 | 1.91% | ||
| Flores, Pete | R | 45 | 2408 | 1.87% | ||
| Campbell, Donna | R | 0 | 2408 | 0.00% |
