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| Senator | Party | Times Disagreed | Total Votes | Percentage | Sort by | |
| Eckhardt, Sarah | D | 639 | 2235 | 28.59% | ||
| Gutierrez, Roland | D | 620 | 2294 | 27.03% | ||
| Johnson, Nathan | D | 567 | 2405 | 23.58% | ||
| Menéndez, José | D | 565 | 2408 | 23.46% | ||
| Alvarado, Carol | D | 558 | 2408 | 23.17% | ||
| Miles, Borris | D | 556 | 2402 | 23.15% | ||
| Whitmire, John | D | 549 | 2408 | 22.80% | ||
| West, Royce | D | 524 | 2320 | 22.59% | ||
| Zaffirini, Judith | D | 527 | 2408 | 21.89% | ||
| LaMantia, Morgan | D | 511 | 2397 | 21.32% | ||
| Blanco, César | D | 507 | 2408 | 21.05% | ||
| Hinojosa, Juan | D | 384 | 2402 | 15.99% | ||
| Hall, Bob | R | 319 | 2408 | 13.25% | ||
| Middleton, Mayes | R | 296 | 2408 | 12.29% | ||
| Hughes, Bryan | R | 287 | 2408 | 11.92% | ||
| Schwertner, Charles | R | 219 | 2408 | 9.09% | ||
| Nichols, Robert | R | 206 | 2405 | 8.57% | ||
| Perry, Charles | R | 192 | 2408 | 7.97% | ||
| Hancock, Kelly | R | 187 | 2405 | 7.78% | ||
| Creighton, Brandon | R | 181 | 2408 | 7.52% | ||
| Parker, Tan | R | 176 | 2408 | 7.31% | ||
| Kolkhorst, Lois | R | 170 | 2354 | 7.22% | ||
| Campbell, Donna | R | 170 | 2408 | 7.06% | ||
| King, Phil | R | 147 | 2270 | 6.48% | ||
| Flores, Pete | R | 155 | 2408 | 6.44% | ||
| Birdwell, Brian | R | 148 | 2316 | 6.39% | ||
| Paxton, Angela | R | 151 | 2408 | 6.27% | ||
| Sparks, Kevin | R | 145 | 2316 | 6.26% | ||
| Bettencourt, Paul | R | 147 | 2354 | 6.24% | ||
| Huffman, Joan | R | 150 | 2408 | 6.23% | ||
| Springer, Drew | R | 0 | 2408 | 0.00% |
